We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

This is the best-performing FTSE 100 stock of the last 40 years

The best FTSE 100 stock of the last 40 years may surprise readers. To be able to retire, I want to buy the best performing stock of the next 40 years too.

| More on:
Content white businesswoman being congratulated by colleagues at her retirement party

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Twelfth Magpie’s Premium Investing Services. Become a member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn more, and get a free 'Best Buy Now' stock!.

With the FTSE 100 celebrating its 40th year in 2024, it’s high time to talk about its best performers, both now, and (potentially) in the future.

So I’ve found the FTSE 100 company that produced the highest stock market returns between 1984 and 2024.

Should you buy hVIVO Plc shares today?

Before you decide, please take a moment to review this report first. Despite ongoing uncertainties from US tariffs to global conflicts, Mark Rogers and his team believe many UK shares still trade at substantial discounts, offering savvy investors plenty of potential opportunities to learn about.

That’s why this could be an ideal time to secure this valuable research – Mark’s analysts have scoured the markets to reveal 5 of his favourite long-term ‘Buys’. Please, don’t make any big decisions before seeing them.

And as a 40-something writer, I reckon I won’t be able to retire until my early 80s. It will be the 2060s by then.

The government is already suggesting the retirement age will have to rise to age 71 by 2034.

So I also want investments that will perform fantastically well over the next 40 years.

Cream of the crop

In total, since 1984, the FTSE 100 has climbed 673%. This a better return than holding gold, or UK government bonds.

As a long-term investor I want to keep one eye on the future, because markets will always have ups and downs.

From the dotcom crash to the Great Financial Crisis, and then the pandemic. These events seemed like the end of the world. But a stock market recovery always followed

And taking the prize of the best-performing FTSE 100 stock of the last 40 years is the scientific publisher RELX.

It was first admitted to the London Stock Exchange in 1948. Its best known properties are the journals The Lancet, Law360 and ScienceDirect.

If I’d invested £100 in 1984 and reinvested all dividends, I’d have over £35,000 today.

This is a better performance than any other Footsie stock.

Simple facts

Longevity creates success and what we find about the most successful companies is that often, they…

  • Generate lots of cash
  • Increase their dividend consistently
  • Bring in business leaders to drive growth

It now makes £2bn of profit every year. Aside from one blip in 2011, it has improved its dividend every year since 2004.

Picking future winners

I’ll put forward my pick for the stock I own that I think will outperform over the next 40 years too.

£205m market cap Hvivo (LSE:HVO) conducts trials in which volunteers are exposed to viruses in a controlled lab setting. This is controversial. If the human challenge model falls out of favour, this could affect its future.

But using this method, Hvivo’s clients can bring vaccines to market relatively quickly.

In April 2023 the US drug regulator granted Nasdaq-listed SAB Biotherapeutics Fast Track status for its medicine for seasonal flu.

This came after using Hvivo’s data, lab services and human challenge model. And the multi-million pound contract wins keep on coming.

Replacing Cathal Friel as CEO with Dr Yamin Khan was a strong move. Friel is a great sales guy but without the biotech experience necessary to drive a company like this forward.

More recently, it has brought technical specialists onto its board. These include Elaine Sullivan, who was in management at Eli Lilly and Astrazeneca.

The upshot

Hvivo will start paying its first dividends in 2024. It has £37m cash in the bank and clients pay up front for access to its clinics.

It recently moved to a larger facility in Canary Wharf and is targeting £100m in revenue by 2028.

It’s nowhere near the FTSE 100 yet, but I see strong growth, dividends and cash generation making Hvivo one of the UK’s best performers by 2064.

Tom Rodgers has positions in Hvivo Plc. The Motley Fool UK has recommended AstraZeneca Plc, British American Tobacco P.l.c., and RELX. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Rolls-Royce's Pearl 10X engine series
Investing Articles

Up nearly 1,400% in 5 years! But are Rolls-Royce shares still secretly undervalued?

After skyrocketing, Rolls-Royce shares are now near an all-time high, but could the engineering giant still have more room to…

Read more »

Happy senior couple hugging and enjoying retirement at home
Investing Articles

By mid-2027, analysts expect £5,000 in Barclays shares to be worth…

Barclays shares have outperformed the FTSE 100 by a wide margin over the last year. And City analysts expect to…

Read more »

Man hanging in the balance over a log at seaside in Scotland
Investing Articles

Near 5-year lows, here’s what the experts say about the Diageo share price

Ben McPoland's questioning his sanity after investing in Diageo. Where do institutional analysts see its share price heading over the…

Read more »

British Airways cabin crew with mobile device
Investing Articles

Up 165% but still with a P/E of 7.9. Is the IAG share price a generational bargain?

The IAG share price has been on fire for the last two years, delivering some of the biggest returns in…

Read more »

Emma Raducanu for Vodafone billboard animation at Piccadilly Circus, London
Investing Articles

Here’s the latest Vodafone share price forecasts for 2027

Up 35% in 12 months, the Vodafone share price is beating the stock market right now, but can this momentum…

Read more »

Close-up image depicting a woman in her 70s taking British bank notes from her colourful leather wallet.
Investing For Beginners

At almost 20-year highs, here’s where the experts think the Barclays share price could go from here

Jon Smith points out that the Barclays share price could still move higher in the coming year, with several positive…

Read more »

Pakistani multi generation family sitting around a table in a garden in Middlesbourgh, North East of England.
Investing Articles

From £5k to £12.4k! Is the current Tesco share price still a bargain?

The Tesco share price has more than doubled investors' money since 2021, but is the stock still a bargain buy…

Read more »

Joyful mature couple having fun together enjoying vacation on city street. Two retired older people enjoying time together during autumn holidays or weekend getaway
Investing Articles

How I’m using a £20k ISA to aim for a £9,982 yearly second income in retirement

Harvey Jones shows how he hopes to generate a bumper second income from investing in FTSE 100 dividend stocks without…

Read more »