We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

Should You Ditch GlaxoSmithKline plc And Buy Vectura Group PLC And SkyePharma PLC?

Are these 2 pharmaceutical stocks better buys that GlaxoSmithKline plc (LON: GSK)? Check out Vectura Group PLC (LON: VEC) and SkyePharma PLC (LON: SKP).

You’re reading a free article with opinions that may differ from The Twelfth Magpie’s Premium Investing Services. Become a member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn more, and get a free 'Best Buy Now' stock!.

With the stock market having been akin to a rollercoaster ride so far in 2016, many investors are understandably seeking out defensive stocks. This makes sense because a volatile portfolio is never much fun and can lead to a great deal of worry and the potential for sleepless nights.

One stock that offers defensive characteristics is GlaxoSmithKline (LSE: GSK). Part of the reason for this is the fact that its profitability is less positively correlated to the performance of the global economy than is the case for most of its FTSE 100 peers. In other words, GlaxoSmithKline depends less on GDP growth and more on a strong drugs pipeline for its bottom-line growth. As such, even if there’s further volatility in share prices, GlaxoSmithKline could continue to outperform the FTSE 100, as it has done since the turn of the year, by over 5%.

Should you buy Rolls Royce shares today?

Before you decide, please take a moment to review this report first. Despite ongoing uncertainties from US tariffs to global conflicts, Mark Rogers and his team believe many UK shares still trade at substantial discounts, offering savvy investors plenty of potential opportunities to learn about.

That’s why this could be an ideal time to secure this valuable research – Mark’s analysts have scoured the markets to reveal 5 of his favourite long-term ‘Buys’. Please, don’t make any big decisions before seeing them.

In addition, GlaxoSmithKline also pays a superb dividend. It currently yields 5.8% and although dividends are due to flatline over the next couple of years as the company implements a major restructuring programme, its shareholder payouts remain relatively high and consistent. During a period of uncertainty this is a superb ally for nervous investors.

As well as defensive attributes, GlaxoSmithKline also has a strong pipeline of new drugs that have the potential to rapidly increase its sales and profit over the medium-to-long term. In fact, GlaxoSmithKline’s portfolio is one of the most diversified in the business and it has real potential to generate multiple blockbuster drugs, with its ViiV Health Care subsidiary being of key importance to the company’s long-term growth. And with its bottom line due to be positively impacted by cost cuts, GlaxoSmithKline seems to be an excellent buy for the long term.

What’s the alternative?

Of course, it’s not the only stock in the pharmaceutical sector that could be worth adding to your portfolio. In fact, there are a number of companies that offer tremendous forecast growth rates and yet trade on highly appealing valuations.

For example, airways diseases specialist Vectura (LSE: VEC) is forecast to increase its bottom line by 116% in the next financial year following what’s expected to be a profitable year in 2016. And with its shares trading on a price-to-earnings (P/E) ratio of 53, this equates to a price-to-earnings growth (PEG) ratio of only 0.5. This indicates that they could deliver improved performance following their fall of 8% in the last six months.

Similarly, drug delivery specialist SkyePharma (LSE: SKP) is due to post a rise in its bottom line of 51% in 2016. When combined with its P/E ratio of 25.6, this equates to a PEG ratio of only 0.5 and indicates that there’s considerable upside potential. As with Vectura, SkyePharma pays no dividend and isn’t expected to commence shareholder payouts this year. In addition, the two companies are much smaller than GlaxoSmithKline and arguably offer less defensive characteristics or stability, but do have greater growth potential.

As such, a mix of all three stocks seems to be a sound move, although for investors who are only able to buy one of the three companies, GlaxoSmithKline appears to have the perfect mix of growth, income and defensive qualities.

Peter Stephens owns shares of GlaxoSmithKline. The Motley Fool UK has recommended GlaxoSmithKline. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

How much do you need in a Stocks and Shares ISA to generate £100 a day in passive income?

Andrew Mackie looks at what it takes to build a meaningful passive income inside a Stocks and Shares ISA and…

Read more »

Front view of a young couple walking down terraced Street in Whitley Bay in the north-east of England they are heading into the town centre and deciding which shops to go to they are also holding hands and carrying bags over their shoulders.
Investing Articles

How much second income would it take to cover household bills?

Andrew Mackie explores how a Stocks and Shares ISA could be used to generate a second income capable of covering…

Read more »

Young Caucasian man making doubtful face at camera
Investing Articles

This FTSE 100 share pays no dividends. Could that change?

This well-known FTSE 100 share is cash flow positive but does not pay a dividend. Why is that -- and…

Read more »

Two white male workmen working on site at an oil rig
Investing Articles

At almost £6, does the BP share price reflect a new energy future, or just the old oil world?

Mark Hartley examines how geopoliticals are driving the BP share price higher, while its key role in the UK’s energy…

Read more »

Portrait of pensive bearded senior looking on screen of laptop sitting at table with coffee cup.
Growth Shares

This high-risk, high-reward penny stock could be primed to rocket from 0.3p

Jon Smith talks through a mining penny stock that is high risk but could offer a big return if it…

Read more »

Girl buying groceries in the supermarket with her father.
Investing Articles

If you’d put £10,000 into Tesco shares 5 years ago, how much richer would you be now?

Ben McPoland takes a look at how much 4,444 Tesco shares bought half a decade ago would have returned, including…

Read more »

This way, That way, The other way - pointing in different directions
Investing For Beginners

My friend says this is the best cheap share in the market. Is he correct?

Jon Smith mulls a potential cheap share that could offer large returns but is a high-risk option given its recent…

Read more »

Aerial shot showing an aircraft shadow flying over an idyllic beach
Investing Articles

How much would you need to invest in FTSE 100 shares to target a £3,000 annual passive income?

Fancy thousands of pounds a year in passive income paid by blue-chip companies? Our writer explains some ins and outs…

Read more »