We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

Why Shire PLC’s Takeover Response Is Highly Unusual

After Abbvie’s £27bn takeover offer was rejected, Shire PLC (LON: SHP) has responded in a rather unusual way…

| More on:

You’re reading a free article with opinions that may differ from The Twelfth Magpie’s Premium Investing Services. Become a member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn more, and get a free 'Best Buy Now' stock!.

shireJust over two months ago, shares in Shire (LSE: SHP) had made next to no gains in 2014. However, following various takeover rumours and then a bid from US healthcare giant, Abbvie, Shire has now posted capital gains of over 50% during the last six months. Great news for shareholders (especially when the FTSE 100 is up only 1% over the same timeframe).

However, things could be about to get a whole lot better for investors in Shire, since management in the company has outlined the sales potential of its pipeline in order, it says, to show Abbvie’s bid significantly undervalued the company.

Should you buy AstraZeneca Plc shares today?

Before you decide, please take a moment to review this report first. Despite ongoing uncertainties from US tariffs to global conflicts, Mark Rogers and his team believe many UK shares still trade at substantial discounts, offering savvy investors plenty of potential opportunities to learn about.

That’s why this could be an ideal time to secure this valuable research – Mark’s analysts have scoured the markets to reveal 5 of his favourite long-term ‘Buys’. Please, don’t make any big decisions before seeing them.

Accurate Projections?

Of course, Shire’s decision to lay out the potential sales figures from its pipeline is unusual because outcomes from pipelines are notoriously difficult (if not impossible) to accurately predict. For example, a pharmaceutical company could have ten drugs in its pipeline, with all of them showing strong prospects in early stage trials. However, when more stringent trials are undertaken, a number of those drugs could fail to deliver when put under greater scrutiny and, more importantly, there seems to be only a limited scope to ascertain which ones could make it through clinical trials and become blockbusters.

In addition, while Shire may be accurate in its sales projections for its pipeline, it may not be able to accurately predict what other drugs will be marketed by the time its own drugs are approved. For example, Shire’s pipeline may contain two drugs that perform well throughout trials and are approved. However, a competitor may have a drug approved during that time that is either cheaper or performs better, thus sidelining Shire’s own, new drug.

Is Shire Worth More Than Its Current Share Price?

Having risen by 50% already this year, there could be better value elsewhere since Shire currently trades on a price to earnings (P/E) ratio of 22.6. This does not compare favourably to sector peers, GlaxoSmithKline (LSE: GSK) (NYSE: GSK.US) and AstraZeneca (LSE: AZN) (NYSE: AZN.US), which have P/Es of 15.2 and 17.5 respectively.

Furthermore, GlaxoSmithKline and AstraZeneca offer yields of 5.2% and 3.8%, while Shire’s yield of 0.4% is very low indeed. As with Shire, GlaxoSmithKline and AstraZeneca both have strong pipelines that could also prove to be targets for sector peers (as shown by Pfizer’s recent bid for AstraZeneca). Certainly, they may not be able to match Shire’s growth potential over the short term, but appear to offer sufficient diversity and resilience in their respective pipelines to ensure that they deliver impressive earnings growth in the long run.

As such, while Shire could yet be the recipient of further bids, GlaxoSmithKline and AstraZeneca could prove to be long-term winners for investors.

Peter owns shares in GlaxoSmithKline and AstraZeneca. The Motley Fool has recommended shares in GlaxoSmithKline and Shire.

More on Investing Articles

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

How much do you need in a Stocks and Shares ISA to generate £100 a day in passive income?

Andrew Mackie looks at what it takes to build a meaningful passive income inside a Stocks and Shares ISA and…

Read more »

Front view of a young couple walking down terraced Street in Whitley Bay in the north-east of England they are heading into the town centre and deciding which shops to go to they are also holding hands and carrying bags over their shoulders.
Investing Articles

How much second income would it take to cover household bills?

Andrew Mackie explores how a Stocks and Shares ISA could be used to generate a second income capable of covering…

Read more »

Young Caucasian man making doubtful face at camera
Investing Articles

This FTSE 100 share pays no dividends. Could that change?

This well-known FTSE 100 share is cash flow positive but does not pay a dividend. Why is that -- and…

Read more »

Two white male workmen working on site at an oil rig
Investing Articles

At almost £6, does the BP share price reflect a new energy future, or just the old oil world?

Mark Hartley examines how geopoliticals are driving the BP share price higher, while its key role in the UK’s energy…

Read more »

Portrait of pensive bearded senior looking on screen of laptop sitting at table with coffee cup.
Growth Shares

This high-risk, high-reward penny stock could be primed to rocket from 0.3p

Jon Smith talks through a mining penny stock that is high risk but could offer a big return if it…

Read more »

Girl buying groceries in the supermarket with her father.
Investing Articles

If you’d put £10,000 into Tesco shares 5 years ago, how much richer would you be now?

Ben McPoland takes a look at how much 4,444 Tesco shares bought half a decade ago would have returned, including…

Read more »

This way, That way, The other way - pointing in different directions
Investing For Beginners

My friend says this is the best cheap share in the market. Is he correct?

Jon Smith mulls a potential cheap share that could offer large returns but is a high-risk option given its recent…

Read more »

Aerial shot showing an aircraft shadow flying over an idyllic beach
Investing Articles

How much would you need to invest in FTSE 100 shares to target a £3,000 annual passive income?

Fancy thousands of pounds a year in passive income paid by blue-chip companies? Our writer explains some ins and outs…

Read more »