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Up 7.5% in a week! Is the GSK share price about to do an AstraZeneca?

Harvey Jones says the GSK share price has dramatically underperformed FTSE 100 rival AstraZeneca, which has had a stellar run. Now it’s ready to play catch-up.

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When I first started writing for The Motley Fool more than two decades ago, the GSK (LSE: GSK) share price was a FTSE 100 shining light.

In my recollection, GlaxoSmithKline, as it was known then, even outshone pharmaceutical sector rival AstraZeneca (LSE: AZN). It’s a different story today.

Should you buy AstraZeneca Plc shares today?

Before you decide, please take a moment to review this report first. Despite ongoing uncertainties from US tariffs to global conflicts, Mark Rogers and his team believe many UK shares still trade at substantial discounts, offering savvy investors plenty of potential opportunities to learn about.

That’s why this could be an ideal time to secure this valuable research – Mark’s analysts have scoured the markets to reveal 5 of his favourite long-term ‘Buys’. Please, don’t make any big decisions before seeing them.

A tale of two pharma stocks

Since taking the helm in October 2012, CEO Pascal Soriot has transformed AstraZeneca into the UK’s biggest company. Last summer, its market-cap topped £200bn. Although today it’s down to £166bn.

Since the start of the Millennium in January 2000, AstraZeneca’s share price has soared from 2,395p to 10,775p, an impressive increase of around 350%. And that’s before accounting for dividends.

By contrast, GSK’s journey has been more turbulent. From a high of 1,767p in January 2000, its share price has dipped to 1,482p today. While dividends have cushioned the blow, it’s a stark comparison to AstraZeneca’s meteoric rise.​

GSK’s dividend, once seen as a stellar source of income with a typical yield of between 5% and 6%, isn’t what it was. It was frozen at 80p from 2014 to 2021, as CEO Emma Walmsley diverted shareholder cash into R&D, in a bid to replenish the group’s ailing drugs pipeline.

Dividends have slipped

It was then reduced to 57.75p in 2022 following the Haleon spin-off. In 2024, it edged up to 61p, offering a yield of 4.1%.​

Now there’s a glimmer of hope. GSK’s recent Q1 2025 results, published on 30 April, reignited investor interest, pushing the share price up by 7.5% over the past week. Although it’s still down 11% over 12 months.

The company reported sales of £7.52bn, a 4% increase year-on-year. Specialty Medicines were the standout, with sales up 17%, including a 28% rise in Respiratory, Immunology, and Inflammation, and a 53% surge in Oncology. 

Operating profit jumped 50%, while cash generated from operations exceeded £1bn, with free cash flow of £700m.

GSK expects to pay a full-year dividend of 64p per share, up almost 5%, and announced a £2bn share buyback, with £273m repurchased in Q1. 

The company also reaffirmed its full-year guidance, anticipating 3-5% turnover growth and a 6-8% rise in core EPS.

Different stocks, different values

AstraZeneca’s Q1 results, released a day earlier, showed a 10% increase in total revenue to $13.6bn and a 21% rise in core EPS to $2.49. Market reaction was muted, perhaps due to the high expectations set by its recent performance. The AstraZeneca share price is up 3.5% in a week, but like GSK, is down 11% over 12 months.

I don’t hold AstraZeneca shares. Last year, I deemed them too pricey. Instead, I placed my bets on GSK, viewing it as an undervalued opportunity

So far, that decision has left me about 20% down, not helped by concerns over potential US tariffs on pharmaceutical imports. Walmsley believes the company can navigate these challenges through AI integration and supply chain adjustments. We’ll see.

As a contrarian investor, I’m inclined to stick with GSK. There’s potentially more value here, with a price-to-earnings ratio of just over eight, less than half AstraZeneca’s P/E of 17. The recent uptick is encouraging, but there’s still a long road ahead. I’m hoping Walmsley’s masterplan will start paying off, but despite the recent jump, I suspect there’s a long way to go. 

Harvey Jones has positions in GSK. The Motley Fool UK has recommended AstraZeneca Plc and GSK. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

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