We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

3 top FTSE 100 shares to consider for a new ISA

The FTSE 100 is packed with top-notch companies that can form the building blocks of a quality Stocks and Shares ISA portfolio.

| More on:
UK financial background: share prices and stock graph overlaid on an image of the Union Jack

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Twelfth Magpie’s Premium Investing Services. Become a member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn more, and get a free 'Best Buy Now' stock!.

Some people will just be starting out on their investing journeys in April. While exciting, it can also be daunting looking at all the options. Where on earth to start? Here, I’ll highlight a trio of high-quality FTSE 100 shares that I think are worth considering for a new ISA portfolio.

Pharmaceutical giant

Big Pharma often gets a bad rep nowadays, but where would millions of patients be without the life-saving medicines? AstraZeneca (LSE: AZN) is the UK’s largest listed company and a world leader in oncology (cancer treatments).

Should you buy AstraZeneca Plc shares today?

Before you decide, please take a moment to review this report first. Despite ongoing uncertainties from US tariffs to global conflicts, Mark Rogers and his team believe many UK shares still trade at substantial discounts, offering savvy investors plenty of potential opportunities to learn about.

That’s why this could be an ideal time to secure this valuable research – Mark’s analysts have scoured the markets to reveal 5 of his favourite long-term ‘Buys’. Please, don’t make any big decisions before seeing them.

Last year, total revenue jumped 21% at constant exchange rates to $54.1bn, while core earnings per share (EPS) increased 19%. By 2030, it’s aiming to launch at least 20 new medicines and reach $80bn in revenue, with sustained growth thereafter. 

At £111 a pop, the shares are trading at 16.5 times forward-looking earnings. I think this is a reasonable valuation for a high-quality global company, though it could always suffer a key clinical trial or regulatory setback. These are unavoidable risks in the industry.

Still, AstraZeneca’s fundamentals are rock-solid. It’s very profitable, excellently run, and has attractive long-term growth opportunities. The stocks also offers a dividend, with the forward yield at 2.3%.

All this makes it an excellent candidate for a new ISA, in my opinion.

Leading credit bureau

From a pharma giant to a data one now with Experian (LSE: EXPN). The credit reporting company possesses a vast collection of data on consumers and businesses, mainly related to credit and financial behaviour. Its tools also help detect and prevent identity fraud.

For the six months to 30 September, revenue was up 7% to $3.6bn, with EPS rising 9%. For the full year that just ended in March, Experian expects organic revenue growth of 6%-8%.

While these might not seem exciting growth rates, it’s important to remember that many lenders, insurers and marketers rely on Experian. This means a large chunk of its revenue is recurring, making it very stable and predictable.

Importantly, its high-quality datasets are a goldmine for training AI models, something it has been doing for two decades. Generative AI is merely strengthening its business further.

Experian has just acquired ClearSale, a leading digital fraud prevention provider in Brazil. This adds e-commerce transactions, mobile phone and device data to the mix, strengthening its products and competitive position in Latin America’s largest economy. 

The possibility of a consumer data breach is a risk, as this would cause significant reputational damage. Meanwhile, the stock isn’t cheap, trading at 25.5 times forward earnings. It’s priced for steady long-term growth, which will have to continue.

I’m bullish on the stock though. Digital lending in the form of buy now, pay later is exploding worldwide, which should continue benefiting Experian. 

Technology fund

Finally, I think Polar Capital Technology Trust is worth considering Too. This investment trust offers wide exposure to many global tech titans, including Nvidia, Broadcom, Apple, and Meta Platforms.

The share price has almost doubled in five years. However, it hasn’t always been a smooth ride and more bumps in the road are guaranteed. Right now, for example, President Trump’s tariff policies could cause earnings volatility at global tech companies.

However, longer term, I expect this trust to increase in value as the ongoing digital/AI revolution gathers steam.

Randi Zuckerberg, a former director of market development and spokeswoman for Facebook and sister to Meta Platforms CEO Mark Zuckerberg, is a member of The Motley Fool's board of directors. Ben McPoland has positions in AstraZeneca Plc. The Motley Fool UK has recommended Apple, AstraZeneca Plc, Experian Plc, Meta Platforms, and Nvidia. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Joyful mature couple having fun together enjoying vacation on city street. Two retired older people enjoying time together during autumn holidays or weekend getaway
Investing Articles

How much do you need in an ISA to target a £20,153 annual passive income on top of your State Pension?

Harvey Jones says the State Pension is nowhere near enough to fund a comfortable retirement, so you need to save…

Read more »

Smartly dressed middle-aged black gentleman working at his desk
Investing Articles

Near 5-year lows, here’s what the experts say about Greggs shares

Greggs’ shares went from a powerful growth story in 2024 to one of the FTSE 250’s worst-performing shares. Do experts…

Read more »

Investing Articles

How investing £20k in a Stocks and Shares ISA could generate a £15,815 yearly passive income for life

Harvey Jones shows how a single lump sum invested in a Stocks and Shares ISA can generate a high and…

Read more »

Investing Articles

Here are 3 cash-covered 7%-yielding FTSE 250 dividend shares with 30+ years of payouts

The FTSE 250 can be a minefield if you don't know what to look for. Mark Hartley breaks down his…

Read more »

Seniors having fun on bicycles in spring landscape
Investing Articles

With a 5.4% yield, 100 shares of this dividend stock could pay £250 of passive income

Our writer thinks this FTSE 250 bank stock still looks great value today, despite skyrocketing 303% over the past five…

Read more »

Landlady greets regular at real ale pub
Investing Articles

By mid-2027, analysts expect £10,000 in Diageo shares to be worth…

Diageo shares have tanked amid concerns over long-term demand for alcohol beverages. Is there the possibility of a rebound in…

Read more »

Wall Street sign in New York City
Investing Articles

UK investors are buying this stunning S&P 500 stock over Microsoft, Netflix and Nvidia. Why?

If you haven't heard of this S&P 500 growth stock yet, you soon will. British investors are keen but Harvey…

Read more »

Overjoyed exited middle aged married couple giving high five, finishing doing domestic paperwork together at home. Euphoric happy older mature spouses celebrating successful investment or purchase.
Investing Articles

How much do you need in an ISA to target a second income of £1,744 a month?

Harvey Jones shows how regular investing in FTSE 100 shares can build a generous second income for retirement, with minimum…

Read more »