We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

If I could choose only one FTSE 100 stock, this would be it

Mark Hartley considers which FTSE 100 stock would be the best option if he had to buy and hold only one forever. Is this pharma giant a clear winner?

| More on:
Engineer Project Manager Talks With Scientist working on Computer

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Twelfth Magpie’s Premium Investing Services. Become a member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn more, and get a free 'Best Buy Now' stock!.

Key Points

  • Up 76% in five years
  • Defensive stock with long-term resilience
  • High price-to-earnings (P/E) ratio of 34.9

When investing, the golden rule is to diversify. The FTSE 100 is full of stocks from different industries and sectors, each with their own unique value proposition. By mixing and matching a variety of stocks, I can protect myself from unexpected slumps in certain sectors.

However, for the sake of experimentation, I’m considering which stock I would pick if I were forced to choose only one. This exercise forces me to carefully evaluate the true potential of a company and its long-term growth prospects. I can’t just dump it on a whim — this would be a lifetime commitment!

Should you buy AstraZeneca Plc shares today?

Before you decide, please take a moment to review this report first. Despite ongoing uncertainties from US tariffs to global conflicts, Mark Rogers and his team believe many UK shares still trade at substantial discounts, offering savvy investors plenty of potential opportunities to learn about.

That’s why this could be an ideal time to secure this valuable research – Mark’s analysts have scoured the markets to reveal 5 of his favourite long-term ‘Buys’. Please, don’t make any big decisions before seeing them.

So with that said, which stock would I pick?

Healthcare isn’t going anywhere

Out of all the stocks on the London Stock Exchange, I would have to choose AstraZeneca (LSE:AZN). The pharma giant made its name during the pandemic as one of the most rapid and successful developers of a Covid vaccine. With a £164bn market cap, it’s the second largest constituent on the FTSE 100 after Shell.

AstraZeneca has been on my radar for as long as I can remember. But recent performance has made me hesitant to buy. After the lingering effects of the pandemic wore off, the share price began to falter. It’s now down 10% in the past year to £105 from a high of £123 in April 2023. But a correction is expected following five years of solid growth that saw it add 76% to the share price.

Strength and resilience

The long-term value proposition of AstraZeneca is resilience during tough times. It has the key characteristic of a defensive stock — a service that is in high demand even during economic uncertainty.

Many pharmaceutical companies researched Covid but AstraZeneca stood out as a leader in advancing a vaccine. It’s a company with the resources and experience to excel when faced with a high-pressure situation. Covid is unlikely to be the last pandemic, and AstraZeneca is now well-positioned as a go-to option for governments seeking help.

Besides vaccine development, AstraZeneca is working on several breakthrough treatments. Tumour drugs Daiichi and Enhertu were recently approved in the US. People are living longer, so demand for such treatments is expected to increase. With a broad range of treatments, the company is less at risk of losses from a single product failure.

Risks and competition

Yet the pharmaceutical industry is very competitive and while AstraZeneca is leading in the UK, it could easily be outmatched. It faces stiff competition from the likes of AbbVie, Novartis and Pfizer. A recent plan to increase the CEO’s pay was branded necessary to remain competitive. But it was opposed by two influential shareholders, with others urged to follow suit.

At an eye-watering £105 per share, the price-to-earnings (P/E) ratio of 34.9 is considerably higher than the industry average of 24.9. This is also reflected in a high price-to-book (P/B) ratio of 5.3, above the industry average of 2.4 and a metric ideally kept below 1.

The high share price would understandably make AstraZeneca less attractive to many investors. However, I still feel it would be the best option if I had to choose and hold just one stock forever.

Mark Hartley has positions in Shell Plc. The Motley Fool UK has recommended AstraZeneca Plc. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

UK financial background: share prices and stock graph overlaid on an image of the Union Jack
Investing Articles

By mid-2027, £5,000 in this FTSE 250 stock could grow to £8,200, if analysts are right

FTSE 250 stock Raspberry Pi is up almost 50% over the last year. And analysts at Peel Hunt expect the…

Read more »

British flag, Big Ben, Houses of Parliament and British flag composition
Investing Articles

By mid-2027, analysts expect Barclays’ share price to hit…

Barclays’ share price has pulled back after the bank’s H1 results. However, analysts expect it to rise over the next…

Read more »

Chalkboard representation of risk versus reward on a pair of scales
Growth Shares

I asked ChatGPT which FTSE 250 stock is most sensitive to a stock market crash. It said…

Jon Smith thinks about which companies could be exposed to a stock market crash, but is surprised at one potential…

Read more »

Investing Articles

Here’s how I’m trying to build wealth in my Stocks and Shares ISA over the next 5 years

Ben McPoland highlights an investment in his Stocks and Shares ISA portfolio that he's excited about over the next half-decade…

Read more »

Image of happy young people man and woman in basic clothing thinking and touching chin while looking aside isolated over yellow background
Investing Articles

I asked ChatGPT where Greggs shares might go next and it said… 

Harvey Jones is in two minds about the outlook for Greggs shares and called in artificial intelligence for its view.…

Read more »

Happy senior couple hugging and enjoying retirement at home
Investing Articles

Up 1,320% in 5 years — now check out the Rolls-Royce share price forecast for August 2027

The Rolls-Royce share price has completely smashed it but the big question is where it goes in future. Harvey Jones…

Read more »

Elderly, couple hiking and bird watching with adventure outdoor, hike together and fitness for active lifestyle. Nature, trekking and senior man pointing and woman with binocular, freedom and travel.
Investing Articles

After it rocketed to a 19-year high, here’s what the experts say about the Barclays share price outlook…

Harvey Jones examines why the Barclays share price has been flying lately and what broker forecasts suggest for the year…

Read more »

Man hanging in the balance over a log at seaside in Scotland
Investing Articles

I asked ChatGPT if the Lloyds share price will crash in 2026. It said…

What probability of a Lloyds share price crash does the world's leading artificial intelligence chatbot give? The answer may surprise…

Read more »