We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

Is it too late to buy Open Orphan shares?

Open Orphan’s shares are up over 100% in the past six months. Is there no stopping this specialist pharmaceutical firm?

You’re reading a free article with opinions that may differ from The Twelfth Magpie’s Premium Investing Services. Become a member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn more, and get a free 'Best Buy Now' stock!.

Six months ago, Open Orphan’s (LSE: ORPH) shares hit a low of 13.5p. Fast-forward to February 19th, 2021, the shares hit a high of 32.90p. Could the rapid share price acceleration be attributable to Open Orphan’s knack of winning new contracts?

On March 9th, Open Orphan further grabbed my attention (and I thought of the company as a possible contender for my SIPP) when its subsidiary Venn Life Science secured a contract with Oxford BioTherapeutics in order to advance a breast cancer trial study.  

Should you buy Rolls Royce shares today?

Before you decide, please take a moment to review this report first. Despite ongoing uncertainties from US tariffs to global conflicts, Mark Rogers and his team believe many UK shares still trade at substantial discounts, offering savvy investors plenty of potential opportunities to learn about.

That’s why this could be an ideal time to secure this valuable research – Mark’s analysts have scoured the markets to reveal 5 of his favourite long-term ‘Buys’. Please, don’t make any big decisions before seeing them.

Open Orphan seemed to be a on a roll in winning new business and, for diversification purposes, adding some pharma to my portfolio would be beneficial in the long term.

The firm said the contract was for a phase 1, open-label dose finding study, which would assess the safety, tolerability, pharmacokinetics and preliminary efficacy of ‘OBT076’, a CD205-directed antibody-drug conjugate, in recurrent and metastatic CD205-positive solid tumours and in women with CD205-positive HER2-negative metastatic breast cancer.

The breast cancer trial, if successful, could play a role in beating the fourth most common cause of cancer death in the UK, according to charity Cancer Research.

Open Orphan’s executive chairman Cathal Friel said: “This deal further demonstrates Open Orphan’s ability to execute on its significant pipeline of contracts with important pharmaceutical businesses.”

Expanding market

Over the past six months, the market for vaccine development and testing has grown rapidly, largely due to the outbreak of Covid-19. There is no doubt that this factor has benefited Open Orphan’s shares, and perhaps one of the reasons why the AIM-traded firm’s market capitalisation is growing – currently standing at £192m.

Open Orphan believes that governments and international pharmaceutical companies are making ‘catch-up’ investments in all types of vaccine development to ensure the effects of any global pandemic can be mitigated in the future. This will have a knock-on effect for Open Orphan’s hVIVO facility, the firm’s other commercial specialist service business.

Winning new contracts, an expanding vaccine development market and world class facilities – Open Orphan has Europe’s only 24-bedroom quarantine clinic with onsite virology – all make Open Orphan’s shares an attractive buy for me.

But what are the negatives? There are a few.

The pandemic has created a new type of “gold rush” in Covid-19 pharmaceutical and biotech shares, which might inevitably come to an end. Open Orphan shares could be the victim of hype and over-valuation, and there is a possible danger of buying this share at the top.

Back in October 2020, Open Orphan’s own brokers downplayed the prospects for the company’s share price despite securing a £10m Covid-19 challenge contract with the government. Arden Partners issued a buy rating on the stock with a target price of 32p, and joint broker finnCap also appeared to be backing a conservative outlook indicating a target price of 28p, with the shares trading around 29p today.

Sabuhi Gard has no position in any of the shares mentioned. The Motley Fool UK has no position in any of the shares mentioned. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Space satellite orbiting the earth.
Investing Articles

By mid-2027, analysts expect $3,000 in Tesla stock to be worth…

Tesla stock has taken a backseat to AI chip names recently and this is reflected in its share price. Is…

Read more »

Investing Articles

Is Raspberry Pi stock a future Nvidia?

Are there any similarities between Raspberry Pi and Nvidia? And even if there are, does this make the FTSE 250…

Read more »

piggy bank, searching with binoculars
Investing For Beginners

Down 25% in a week and at 52-week lows, is this UK share now a bargain?

Jon Smith points out a UK share that has been beaten down recently, but could now be undervalued with an…

Read more »

Investing Articles

My favourite FTSE 100 growth stock jumped another 6% today but still trades at a 17% discount!

Harvey Jones is a massive fan of this growth stock and is thrilled to see its shares are climbing again…

Read more »

Elderly, couple hiking and bird watching with adventure outdoor, hike together and fitness for active lifestyle. Nature, trekking and senior man pointing and woman with binocular, freedom and travel.
Investing Articles

Here’s what £5,000 in a best-buy Cash ISA could be worth in July 2027

Harvey Jones says there are some decent Cash ISA rates on the market today but in the longer run stocks…

Read more »

British pound data
Investing Articles

Here’s a £20,000 ISA offering £1,320 a year in passive income

Ben McPoland highlights a five-stock portfolio that could generate a very attractive level of tax-free annual passive income.

Read more »

Investor looking at stock graph on a tablet with their finger hovering over the Buy button
Dividend Shares

By July 2027, £8k paid into a Cash ISA could be worth this much…

Jon Smith explains the benefits of a Cash ISA, but talks through how the elevated reward from dividend shares could…

Read more »

Happy couple hiking together in mountains with backpacks
Investing Articles

Age 50 with £100k in a SIPP? Here’s what it could be worth by age 65….

Harvey Jones does his sums to show how a decent sum of money in a Self-Invested Personal Pension (SIPP) may…

Read more »