We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

Are Synairgen plc or Immupharma plc better investments than AstraZeneca plc?

Should you invest in juniors Synairgen plc (LON:SNG) and Immupharma plc (LON:IMM) or giant AstraZeneca plc (LON:AZN)?

| More on:

You’re reading a free article with opinions that may differ from The Twelfth Magpie’s Premium Investing Services. Become a member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn more, and get a free 'Best Buy Now' stock!.

Junior pharmaceutical stocks have the potential to create huge value for shareholders if successful. These two stocks both have drugs that could create many millions of revenue in the future. Will either outperform pharma giant AstraZeneca (LSE: AZN), though?

Respiratory focus

Synairgen (LSE: SNG) is a drug development company founded by three University of Southampton professors, the business focusing on treating respiratory diseases such as asthma. The company has a potential asthma treatment which is being developed with AstraZeneca after signing a licensing and development deal in 2014. The deal is worth up to $232m plus royalties and the drug entered Phase IIa trials in July 2015. Synairgen hopes to release results on the trials sometime in 2017.

Should you buy AstraZeneca Plc shares today?

Before you decide, please take a moment to review this report first. Despite ongoing uncertainties from US tariffs to global conflicts, Mark Rogers and his team believe many UK shares still trade at substantial discounts, offering savvy investors plenty of potential opportunities to learn about.

That’s why this could be an ideal time to secure this valuable research – Mark’s analysts have scoured the markets to reveal 5 of his favourite long-term ‘Buys’. Please, don’t make any big decisions before seeing them.

The inhaled treatment developed by Synairgen has the potential to be a blockbuster product. Many believe if the drug is approved then AstraZeneca may take over Synairgen to acquire full ownership of the drug. This isn’t the only project in Synairgen’s pipeline: the company recently signed a research collaboration with Pharmaxis to develop a treatment for a fatal lung disease. Chairman Simon Shaw recently commented that “our collaboration with Pharmaxis has begun to yield positive results and we anticipate a Phase I clinical trial in 2017“. 

Lupus treatment

Immupharma (LSE: IMM) is in the process of developing its Lupuzor drug which is currently in Phase III clinical trials at 43 sites across the US and Europe. The company is aiming to release “top line results” by the end of 2017. The potential of the drug is huge and the company thinks the Lupus market has the potential for multi-billion dollar sales. The company made a £3.9m loss last year mainly due to research and development costs which is perfectly normal for a junior pharma stock. Immupharama recently carried out a £8.4m funding round which should fund the company right through to 2018.  It’s clear to me that Immupharama has the potential to make huge returns for shareholders if Lupuzor is brought to the market. Investors should keep an eye on the company next year when initial trial results are expected. 

Exciting pipeline

AstraZeneca is different to the two juniors as it has a pipeline full of new and exciting drugs going through clinical trials. The company pays a chunky 4.8% dividend and trades on an attractive 14.2 times earnings. AstraZeneca has the firepower to make acquisitions in the future which should boost earnings and keep the company moving forward with new drugs and treatments. The defensive qualities of the stock should mean it holds up well after the EU referendum on the 23rd June, and investors looking to shelter cash should take a serious look at the company. Although AstraZeneca is unlikely to give you the huge gains that are possible with Synairgen and Immupharma, it could be a great core holding for the long term. 

Investing in junior pharma stocks is a risky game. The rewards could be massive, but most drugs never make it to market and companies can lose millions in research and development. 

Jack Dingwall has no position in any shares mentioned. The Motley Fool UK has recommended AstraZeneca. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

piggy bank, searching with binoculars
Investing For Beginners

Down 25% in a week and at 52-week lows, is this UK share now a bargain?

Jon Smith points out a UK share that has been beaten down recently, but could now be undervalued with an…

Read more »

Investing Articles

My favourite FTSE 100 growth stock jumped another 6% today but still trades at a 17% discount!

Harvey Jones is a massive fan of this growth stock and is thrilled to see its shares are climbing again…

Read more »

Elderly, couple hiking and bird watching with adventure outdoor, hike together and fitness for active lifestyle. Nature, trekking and senior man pointing and woman with binocular, freedom and travel.
Investing Articles

Here’s what £5,000 in a best-buy Cash ISA could be worth in July 2027

Harvey Jones says there are some decent Cash ISA rates on the market today but in the longer run stocks…

Read more »

British pound data
Investing Articles

Here’s a £20,000 ISA offering £1,320 a year in passive income

Ben McPoland highlights a five-stock portfolio that could generate a very attractive level of tax-free annual passive income.

Read more »

Investor looking at stock graph on a tablet with their finger hovering over the Buy button
Dividend Shares

By July 2027, £8k paid into a Cash ISA could be worth this much…

Jon Smith explains the benefits of a Cash ISA, but talks through how the elevated reward from dividend shares could…

Read more »

Happy couple hiking together in mountains with backpacks
Investing Articles

Age 50 with £100k in a SIPP? Here’s what it could be worth by age 65….

Harvey Jones does his sums to show how a decent sum of money in a Self-Invested Personal Pension (SIPP) may…

Read more »

Joyful mature couple having fun together enjoying vacation on city street. Two retired older people enjoying time together during autumn holidays or weekend getaway
Investing Articles

How much would a 35-year-old need to save to retire early with a second income?

Mark Hartley details exactly how much second income a young investor could expect to earn from savings if they aim…

Read more »

photo of Union Jack flags bunting in local street party
Investing Articles

Here’s what £20,000 invested in the FTSE 100 in July 2025 is worth today…

Harvey Jones flags up just how well the FTSE 100 has done over the last year, and picks out a…

Read more »