We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

GlaxoSmithKline plc Beats AstraZeneca plc And Shire PLC In The Pharmaceuticals Stakes

We compare GlaxoSmithKline plc (LON: GSK), AstraZeneca plc (LSE: AZN) And Shire PLC (LON: SHP) to see which is best.

| More on:

You’re reading a free article with opinions that may differ from The Twelfth Magpie’s Premium Investing Services. Become a member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn more, and get a free 'Best Buy Now' stock!.

AstraZenecaPharmaceuticals companies have been big in the news in recent months. Pfizer’s bid for AstraZeneca (LSE: AZN) (NYSE: AZN.US) pushed the share price skywards, and in the other direction GlaxoSmithKline (LSE: GSK) (NYSE: GSK.US) took a hammering after releasing a profit warning. Shire (LSE: SHP), meanwhile, has seen its share price double over the past 12 months.

But which company is best?

Should you buy AstraZeneca Plc shares today?

Before you decide, please take a moment to review this report first. Despite ongoing uncertainties from US tariffs to global conflicts, Mark Rogers and his team believe many UK shares still trade at substantial discounts, offering savvy investors plenty of potential opportunities to learn about.

That’s why this could be an ideal time to secure this valuable research – Mark’s analysts have scoured the markets to reveal 5 of his favourite long-term ‘Buys’. Please, don’t make any big decisions before seeing them.

Here’s a fundamentals snapshot of the big three:

  GlaxoSmithKline AstraZeneca        Shire       
EPS growth 2013 +1% -26% +77%
P/E 2013 14.4 11.9 18.7
Dividend Yield 2013 4.8% 4.7% 0.4%
Dividend Cover 2013 1.44x 1.80x 12.9x
EPS growth 2014*
-15% -13% +25%
P/E 2014 14.5 15.7 24.7
Dividend Yield 2014 5.9% 4.1% 0.3%
Dividend Cover 2014 1.17x 1.57x 11.9x
EPS growth 2015* +6% -6% +10%
P/E 2015 13.7 16.8 22.5
Dividend Yield 2015 6.1% 4.1% 0.4%
Dividend Cover 2015 1.19x 1.46x 11.7x

* forecast

New boss

AstraZeneca’s big strength is Pascal Soriot, the chief executive who stormed into the top job in October 2012 like a whirlwind. Pledging to return the company to its core strengths of scientific leadership in mainstream drug development, Mr Soriot has been refocusing and pouring cash into beefing up the development pipeline.

And it’s paying off. At first-half time the firm had 14 projects at Phase III, up from 8 a year previously, with a number of new cancer drugs looking very promising.

AstraZenenca shares have not quite subsided from the aborted Pfizer bid, and at 4,117p they’re up 25% over 12 months and on a forward P/E of nearly 16. But with the potential that’s there, I don’t think that’s too bad at all.

What about Shire?

Then there’s relative upstart Shire. Registered in Jersey and headquartered in Ireland, it’s enjoying something of a surge. Earnings per share (EPS) grew by 77% last year, and is up eight-fold since 2008! We’re clearly looking at a great growth story, with the shares doubling to 4,735p in a year, so what’s the bottom line?

Well, Shire is in the process of being taken over by AbbVie Inc, which will provide Shire shareholders with £24.44 in cash plus 0.896 new AbbVie shares per Shire share — valuing Shire at around £53 per share. Shire, then, is not one for long-term investors to consider.

A Glaxo bargain?

That leaves us with GlaxoSmithKline, which I think is showing the most attractive fundamentals in the table above.

GlaxoSmithKlineThe profit warning issued at interim time, suggesting that 2014 core EPS is only likely to be “broadly similar to 2013“, was disappointing. But some of that was due to the strengthening of the pound — it’s up 9% against the dollar over the past 12 months, and that will hurt any multinational company reporting in sterling.

Dividend cover looks like it’s getting a little stretched, but EPS is erratic in this business and the big players can easily cope with low cover for a couple of years — in fact, in 2010 Glaxo paid out a dividend of 65p even though EPS was recorded at only 54p that year. It’s a slight concern, but not a big worry.

The best

So my choice? I actually think GlaxoSmithKline and AstraZeneca are both looking attractive, but Glaxo’s growing dividends, lower P/E valuation, more developed pipeline and lower uncertainty make it my pick of the sector.

Alan Oscroft has no position in any shares mentioned. The Motley Fool has recommended GlaxoSmithKline. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

DIVIDEND YIELD text written on a notebook with chart
Investing Articles

Here’s why Legal & General is still the UK’s most popular dividend stock

There are good reasons why dividend investors have been hoovering up Legal & General stock in 2026, but there are…

Read more »

Young Black woman using a debit card at an ATM to withdraw money
Investing Articles

How to target almost £1,000 a month in second income with a monthly investment strategy

Mark Hartley does the maths to work out how much you should invest in the stock market each month if…

Read more »

Businesswoman calculating finances in an office
Investing Articles

Below £8, this high-growth UK fintech stock looks like a bargain to me

This UK stock has fallen nearly 30% in the space of two months. And Edward Sheldon sees a lot of…

Read more »

British pound data
Investing Articles

Ceres Power shares just crashed 35%! Time to consider buying?

Ceres Power shares, which have been on a tear in 2026, have recently pulled back. Is this a great opportunity…

Read more »

A mature woman help a senior woman out of a car as she takes her to the shops.
Investing Articles

How much do you need in an ISA to earn £19,999 a year on top of the State Pension

Harvey Jones suggests investing in a Stocks and Shares ISA to build a pot of wealth to supplement your State…

Read more »

Female student sitting at the steps and using laptop
Investing Articles

Are Greggs shares really undervalued?

Greggs shares still can't catch a break. Is Paul Summers reconsidering whether to buy this battered FTSE 250 stock?

Read more »

Investor looking at stock graph on a tablet with their finger hovering over the Buy button
Investing Articles

Halma shares down 14%! What on earth is the stock market thinking!?

Halma shares crashed 14% in a day after the firm reported 16.6% revenue growth. Is this the opportunity Stephen Wright…

Read more »

The Ocean Village Marina neighborhood of Southampton on the Channel coast in southern England, UK.
Investing Articles

How much do you need in your SIPP to target a £575 monthly passive income?

Harvey Jones says many investors overlook the attractions of a Self-Invested Personal Pension but it can work nicely alongside an…

Read more »