We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

What’s Next For AstraZeneca plc?

Where will AstraZeneca plc (LON:AZN) go from here?

| More on:

You’re reading a free article with opinions that may differ from The Twelfth Magpie’s Premium Investing Services. Become a member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn more, and get a free 'Best Buy Now' stock!.

Pfizer finally admitted defeat in its quest to acquire AstraZeneca (LSE: AZN) (NYSE: AZN.US) earlier this week. However, with Pfizer backing off, investors are now starting to ask questions about Astra’s future prospects. Specifically, investors want to know if Astra can meet its growth targets set out by management in the company’s defence against the US pharmaceutical giant.

That said, there is some speculation that Pfizer might return for another attempt after the six-month cooling-off period, or three months if Astra’s management invites Pfizer back to the table. On the other hand, with so much political opposition to the original deal, it’s likely that Pfizer won’t return with another offer anytime soon.

Should you buy AstraZeneca Plc shares today?

Before you decide, please take a moment to review this report first. Despite ongoing uncertainties from US tariffs to global conflicts, Mark Rogers and his team believe many UK shares still trade at substantial discounts, offering savvy investors plenty of potential opportunities to learn about.

That’s why this could be an ideal time to secure this valuable research – Mark’s analysts have scoured the markets to reveal 5 of his favourite long-term ‘Buys’. Please, don’t make any big decisions before seeing them.

Lofty forecastsAstraZeneca

Now that Astra has rebuffed Pfizer, the company is going to have its work cut out to meet the lofty growth targets set out by management.

Indeed, Astra’s management turned down Pfizer’s offer as they believed that the company has the potential to achieve better returns for investors over the long term. Astra’s management has forecast that the company’s sales will increase by more than 75% over the next decade, returning to 2013 levels by 2017. 

There is no doubt that this forecast is optimistic and it is based on the success of a number of key drugs, which are currently under development. Actually, Astra is busy showcasing its emerging range of cancer drugs this week on a US roadshow. 

One of the treatments under development, with the most potential, uses anti-PD-L1 antibodies to target cancer cells. Some scientists believe that this treatment could prove as transformational as HIV drugs have been in tackling Aids; redefining the way that cancer patients are treated.

Raising concerns

Nevertheless, Astra’s forecasts are still just forecasts, and the company has to overcome some considerable barriers before it can market these potentially revolutionary drugs. 

For example, many more clinical trials are required before these new treatments can be sold to the public and there is also stiff competition from peers, Bristol-Myers Squibb, Roche, Novartis and Merck & Co.

When considering the barriers Astra still has to overcome, many City analysts believe that the company’s revenue forecasts are too optimistic. Actually, the company is targeting peak annual sales higher than even the most bullish analysts expect. There is a lot of talk that forecasts were inflated to boost the defence against Pfizer.

One of Astra’s top shareholders is so doubtful of these forecasts that it has called for the company’s pay policy to be linked to the spurned £55 price. 

Foolish summary

All in all, Astra has some potentially revolutionary treatments under development, which, if brought to market successfully, could transform the company’s future. 

Nevertheless, Astra still has a huge amount of work to do before these treatments get to market and the list of things that could go wrong is endless. What’s more, with legacy sales falling, Astra’s revenue is going to continue to slide until it gets these new treatments to market. 

Rupert does not own any share mentioned within this article.

More on Investing Articles

Midnight is celebrated along the River Thames in London with a spectacular and colourful firework display.
Investing Articles

Are we on the brink of a stock market crash – or a boom?

Investors are fixated on the SpaceX IPO, while also worrying about a global stock market crash. Harvey Jones's thoughts are…

Read more »

A senior man using hiking poles, on a hike on a coastal path along the coastline of Cornwall.
Investing Articles

How much do you need in a SIPP to target a £1,520 a month retirement income?

Mark Hartley outlines a strategy to beef up retirement income by making careful investments, and optimising them with the tax…

Read more »

A row of satellite radars at night
Investing Articles

3 possible ways to get a Stocks and Shares ISA into the new space age

Elon Musk's SpaceX IPO is dominating the headlines this week, but what might it mean for UK Stocks and Shares…

Read more »

Renewable energies concept collage
Investing Articles

National Grid shares: is this FTSE 100 dividend stock turning into a growth story?

National Grid shares have long been seen as a defensive play, but as electrification accelerates, Andrew Mackie argues it may…

Read more »

Young Black woman looking concerned while in front of her laptop
Investing Articles

BAE shares are falling: opportunity or warning?

Paul Summers takes a closer look at what's going on with BAE shares. Is the recent sell-off actually a wonderful…

Read more »

One English pound placed on a graph to represent an economic down turn
Investing Articles

How much passive income can I get from Lloyds shares at £1 each?

Ben McPoland explores how much passive income he would get back from a £1,000 investment in Lloyds stock today. Will…

Read more »

Wall Street sign in New York City
Investing Articles

What do the early stages of a stock market crash look like?

Christopher Ruane isn't peering into a crystal ball trying to time the next stock market crash. He's getting ready now,…

Read more »

Investing Articles

Has this FTSE 100 growth stock become too cheap to ignore?

Andrew Mackie looks at a FTSE 100 growth stock turnaround story after a sharp post-Covid sell-off and years of disappointing…

Read more »